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Search Results for " trichostatin a "

4

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T29007	Trichostatin A S-isomer (-)-Trichostatin A
	Trichostatin A S-isomer is the s-isomer of Trichostatin A. Trichostatin A is a histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Trichostatin A inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20
T35825	Trichostatin C
	Trichostatin C is a glycosylated derivative of trichostatin A , the antifungal antibiotic that reversibly inhibits histone deacetylase. Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate identified in nature. It has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.
T22489	2'-MeCCPA 2-Chloro-N-cyclopentyl-2′-C-methyladenosine	HCV Protease; Adenosine Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	2'-MeCCPA 是一种具有有效性和高选择性的 A1 腺苷受体 (A1AR) 激动剂，对 AR 的 K 值为 1.8 nM。2'-MeCCPA 抑制毛喉素刺激的腺苷酸环化酶活性，IC值为13.1 nM。2'-MeCCPA 具有镇痛活性，可用于研究 HCV 。
T35812	CAY10591 CAY10591
	Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This com...

化合物

Trichostatin A S-isomer

Cat.No: T29007

Synonym: (-)-Trichostatin A

Trichostatin C

Cat.No: T35825

Cat.No: T22489

Synonym: 2-Chloro-N-cyclopentyl-2′-C-methyladenosine

Target: HCV Protease, Adenosine Receptor

Cat.No: T35812

Synonym: CAY10591

Cat. No.	Product Name	Target	Signaling Pathways
T6270	Trichostatin A 曲古柳菌素A,曲古抑菌素A,TSA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Trichostatin A (TSA) 属于二烯异羟肟酸类的天然衍生物。Trichostatin A 是一种组蛋白去乙酰化酶抑制剂 (IC50=1.8 nM)，具有可逆性和特异性。Trichostatin A 导致核心组蛋白过度乙酰化，从而调节染色质结构。

天然产物

Trichostatin A

Cat.No: T6270

Synonym: 曲古柳菌素A,曲古抑菌素A,TSA

Target: HDAC

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